- manic-depressivesADJIf someone is manic-depressive, they have a medical condition in which they sometimes feel excited and confident and at other times very depressed.
She told them that her daughter-in-law was manic-depressive...
Manic depressive illness affects men and women equally.N-COUNTA manic-depressive is someone who is manic-depressive.
Her mother is a manic depressive.
English dictionary. 2008.